Jun 02, 2012 - The molecular structure of a protein involved in Alzheimer's disease - and the surprising discovery that it binds cholesterol - could lead to new therapeutics for the disease, Vanderbilt University investigators report in the June 1 issue of the journal Science. Charles Sanders, Ph.D., professor of Biochemistry, and colleagues in the Center for Structural Biology determined the structure of part of the amyloid precursor protein (APP) - the source of amyloid-beta, which is believed to trigger Alzheimer's disease... (Source: Health News from Medical News Today)
Jun 01, 2012 - MELBOURNE, June 1 (UPI) -- Dark chocolate lowers blood pressure and cholesterol, making it a cheap and tasty way to lower cardiovascular disease risk, Australian researchers say. (Source: Health News - UPI.com)
Jun 01, 2012 - Two large studies suggest disease-modifying and possible neuroprotective effects of statins in Parkinson's disease, but the results should be interpreted with caution. Journal Watch (Source: Medscape Today Headlines)
Jun 01, 2012 - A section of protein which helps make up amyloid plaques ? a hallmark of Alzheimer?s ? could bind with cholesterol according to research published in the journal Science. (Source: Alzheimers Society)
May 30, 2012 - A new formulation of reconstituted human apoA1 can "dramatically enhance cholesterol efflux from macrophages to serum," according to studies presented by company researchers. (Source: theHeart.org)
May 30, 2012 - Cholesterol-fed zebrafish is an emerging animal model to study metabolic, oxidative, and inflammatory vascular processes relevant to pathogenesis of human atherosclerosis. Zebrafish fed a high-cholesterol diet (HCD) develop hypercholesterolemia and are characterized by profound lipoprotein oxidation and vascular lipid accumulation. Using optically translucent zebrafish larvae has the advantage of monitoring vascular pathology and assessing the efficacy of drug candidates in live animals. Thus, we investigated whether simvastatin and ezetimibe, the principal drugs used in management of hypercholesterolemia in humans, would also reduce cholesterol levels in HCD-fed zebrafish larvae. We found that ezetimibe was well tolerated by zebrafish and effectively reduced cholesterol levels in HCD-fed ...
May 30, 2012 - Chem. Commun., 2012, Accepted ManuscriptDOI: 10.1039/C2CC33410K, CommunicationAvijit Mandal, Nikhil R JanaFluorescence based cholesterol detection method has been developed using competetive host-guest interaction between graphene bound [small beta]-cyclodextrin ([small beta]-CD) with rhodamine 6G (R6G) and cholesterol. Fluorescence of [small beta]-CD incorporated R6G is quenced...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
May 30, 2012 - Conclusions:? The results obtained in the present study suggest that serum RBP4 concentrations in patients with type 2 diabetes may be associated with diabetes?related renal dysfunction and imbalances in lipid metabolism. (Source: Journal of Human Nutrition and Dietetics)
May 29, 2012 - Sipping green tea may help keep your cholesterol in check and boost your defense against heart disease. (Source: About.com Eating Disorders)
May 29, 2012 - Elevated low?density lipoprotein cholesterol (LDL?C) has been the main target of lipid?altering therapy to reduce cardiovascular risk associated with dyslipidemia. Residual cardiovascular risk remains, however, after achievement of goal LDL?C levels and is associated in part with other risk markers of cardiovascular disease, including low high?density lipoprotein cholesterol (HDL?C), high lipoprotein a, and hypertriglyceridemia. Niacin is considered a valuable agent for therapy to modify high LDL?C as well as low HDL?C, high lipoprotein a, and hypertriglyceridemia. The forms of niacin available in the marketplace include unbound niacin, or free nicotinic acid (NA); extended?release NA, a form of NA that is released gradually over a period of time; inositol hexanicotinate,...