Jun 02, 2012 - SAN DIEGO (MedPage Today) -- Many patients with early signs of multiple sclerosis go to an emergency room for care, but, at one big-city hospital, the diagnosis was initially missed in nearly 40% of cases. (Source: MedPage Today Neurology)
Jun 02, 2012 - Although research conducted in a large UK study failed to prove cannabis effective for slowing the progression of Multiple Sclerosis (MS), patients reported marijuana helpful for relieving symptoms of...(PRWeb June 02, 2012)Read the full story at http://www.prweb.com/releases/-medical-marijuana/-information-san-francisc/prweb9568927.htm (Source: PRWeb: Medical Pharmaceuticals)
Jun 01, 2012 - In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells. Here, we identify astrocytic expression of VEGF-A as a key driver of BBB permeability in mice. Inactivation of astrocytic Vegfa expression reduced BBB breakdown, decreased lymphocyte infiltration and neuropathology in inflammatory and demyelinating lesions, and reduced paralysis in a mouse model of MS. Knockdown studies in CNS endothelium indicated activation of the downstream effector eNOS as the principal mechanism underlyi...
Jun 01, 2012 - PURPOSE: Research shows that parenting factors and individual difference variables, such as sensation seeking (SS) and risk perceptions (RPs), are associated with increased motor vehicle crash risk for young drivers. The presence of peer passengers is also... (Source: SafetyLit: All (Unduplicated))
Jun 01, 2012 - The recent US Commodity Flow Survey data suggest that transporting hazardous materials (HAZMAT) often involves multiple modes, especially for long-distance transportation. However, not much research has been conducted on HAZMAT location and routing on a mu... (Source: SafetyLit: All (Unduplicated))
Jun 01, 2012 - Read clinically focused news coverage of key developments from the meeting. Medscape Neurology (Source: Medscape Neurology and Neurosurgery Headlines)
Jun 01, 2012 - AbstractHuman antigen R (HuR) is a post?transcriptional regulator of gene expression that plays a key role in stabilizing mRNAs during cellular stress, leading to enhanced survival. HuR expression is tightly regulated through multiple transcription and post?transcriptional controls. Although HuR is known to stabilize a subset of mRNAs involved in cell survival, its role in the survival pathway of PI3?kinase/Akt signaling is unclear. Here, we show that in renal proximal tubule cells, HuR performs a central role in cell survival by amplifying Akt signaling in a positive feedback loop. Key to this feedback loop is HuR?mediated stabilization of mRNA encoding Grb10, an adaptor protein whose expression is critical for Akt activation. Stimulation of Akt by interaction with Grb10 then acti...
Jun 01, 2012 - Genzyme Corp., the rare disease and multiple sclerosis business of French drug maker a Sanofi (NYSE: SNY), says a Phase 3 trial for its potential oral therapy for MS had a statistically significant reduction in two important measures ? annualized relapse rate and risk of sustained accumulation of disability. The drug candidate, which would be called Aubagio if approved, is already under review at both the U.S. Food and Drug Administration (FDA), and at the European regulatory agency.
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Jun 01, 2012 - (MedPage Today) -- An investigational oral drug for relapsing-remitting multiple sclerosis, teriflunomide (Aubagio), outperformed placebo in the third of five phase III trials, its manufacturer said. (Source: MedPage Today Primary Care)
Jun 01, 2012 - Mol. BioSyst., 2012, Accepted ManuscriptDOI: 10.1039/C2MB25050K, PaperMelissa J Davis, Chang Jin Shin, Ning Jing, Mark RaganTranscriptomics continues to provide ever-more evidence that in morphologically complex eukaryotes each protein-coding genetic locus can give rise to multiple transcripts that differ in length, exon content and/or other sequence...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)